منابع مشابه
Bacterial nucleators: actin' on actin.
The actin cytoskeleton is a key target of numerous microbial pathogens, including protozoa, fungi, bacteria and viruses. In particular, bacterial pathogens produce and deliver virulence effector proteins that hijack actin dynamics to enable bacterial invasion of host cells, allow movement within the host cytosol, facilitate intercellular spread or block phagocytosis. Many of these effector prot...
متن کاملRegulatory interactions between two actin nucleators,
Developing Drosophila melanogaster oocytes use both actin and microtubule cytoskeletal systems to construct and maintain internal landmarks that defi ne the dorsal-ventral and anteriorposterior axes (Theurkauf et al., 1992; Clark et al., 1994; Pokrywka and Stephenson, 1995; Polesello et al., 2002). The cappuccino and spire genes encode actin fi lament nucleation factors (Quinlan et al., 2005), ...
متن کاملActin nucleators in the nucleus: an emerging theme.
Actin is an integral component of the cytoskeleton, forming a plethora of macromolecular structures that mediate various cellular functions. The formation of such structures relies on the ability of actin monomers to associate into polymers, and this process is regulated by actin nucleation factors. These factors use monomeric actin pools at specific cellular locations, thereby permitting rapid...
متن کاملRickettsia Actin-Based Motility Occurs in Distinct Phases Mediated by Different Actin Nucleators
Many intracellular bacterial pathogens undergo actin-based motility to promote cell-cell spread during infection [1]. For each pathogen, motility was assumed to be driven by a single actin polymerization pathway. Curiously, spotted fever group Rickettsia differ from other pathogens in possessing two actin-polymerizing proteins. RickA, an activator of the host Arp2/3 complex, was initially propo...
متن کاملRegulatory interactions between two actin nucleators, Spire and Cappuccino
Spire and Cappuccino are actin nucleation factors that are required to establish the polarity of Drosophila melanogaster oocytes. Their mutant phenotypes are nearly identical, and the proteins interact biochemically. We find that the interaction between Spire and Cappuccino family proteins is conserved across metazoan phyla and is mediated by binding of the formin homology 2 (FH2) domain from C...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Pathogens and Disease
سال: 2015
ISSN: 2049-632X,2049-632X
DOI: 10.1093/femspd/ftv078